Relationship between Hedgehog Signaling Pathway and Drug Resistance of Poorly Differentiated Gliomas

Bull Exp Biol Med. 2018 Jan;164(3):356-361. doi: 10.1007/s10517-018-3989-x. Epub 2018 Jan 8.

Abstract

The effects of Hedgehog signaling inhibitor (cyclopamine) and activator (Shh) on drug resistance of U251-MG human glioma cells and human astrocyte culture to cisplatin, temozolomide, and doxorubicin were studied. Cyclopamine and Shh modified the drug resistance of U251-MG cells but not of human astrocytes. Experiments with cyclopamine, Shh, and chemical drugs can contribute to detection of the mechanisms of signaling effects on the drug resistance processes, while the experimental data can serve as one of the criteria for choosing individual chemotherapy for patients.

Keywords: Hedgehog signaling pathway; Shh polypeptide; cyclopamine; drug resistance; glioblastoma multiforme.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Astrocytes / cytology
  • Astrocytes / drug effects
  • Astrocytes / metabolism
  • Cell Differentiation
  • Cell Line, Tumor
  • Cells, Cultured
  • Cisplatin / pharmacology
  • Dacarbazine / analogs & derivatives
  • Dacarbazine / pharmacology
  • Doxorubicin / pharmacology
  • Drug Resistance, Neoplasm / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Hedgehog Proteins / antagonists & inhibitors
  • Hedgehog Proteins / genetics*
  • Hedgehog Proteins / metabolism
  • Humans
  • Neuroglia / drug effects*
  • Neuroglia / metabolism
  • Neuroglia / pathology
  • Peptides / pharmacology
  • Signal Transduction / genetics*
  • Temozolomide
  • Veratrum Alkaloids / pharmacology

Substances

  • Antineoplastic Agents
  • Hedgehog Proteins
  • Peptides
  • SHH protein, human
  • Veratrum Alkaloids
  • Dacarbazine
  • Doxorubicin
  • Cisplatin
  • Temozolomide
  • cyclopamine