Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies. In addition to the direct effects of NF-κB in cancer cells, it might also impact immune cells that can both promote or prevent tumor development. Currently, with the rise of cancer immunotherapy, the link among immune cells, inflammation, and cancer is a major focus, and NF-κB could be an important regulator for the success of these therapies. This review discusses the contrasting roles of NF-κB as a regulator of pro- and antitumor processes and its potential as a therapeutic target.
Keywords: NF-kB; NF-kappaB; cancer; immune response; inflammation; signaling; therapy; treatment.
Conflict of interest statement
The authors declare no conflicts of interest.
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.Biomedicines. 2018 Jul 27;6(3):82. doi: 10.3390/biomedicines6030082. Biomedicines. 2018. PMID: 30060453 Free PMC article. Review.
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway.J Biol Chem. 2013 Sep 6;288(36):26167-76. doi: 10.1074/jbc.M113.477950. Epub 2013 Jul 31. J Biol Chem. 2013. PMID: 23902772 Free PMC article.
The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vascular Diseases--Is the Activation of NF-κB a Friend or Foe of BMP Function?Vitam Horm. 2015;99:145-70. doi: 10.1016/bs.vh.2015.05.002. Epub 2015 Jun 26. Vitam Horm. 2015. PMID: 26279375 Review.
Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.BMC Genomics. 2010 Dec 2;11 Suppl 4(Suppl 4):S25. doi: 10.1186/1471-2164-11-S4-S25. BMC Genomics. 2010. PMID: 21143809 Free PMC article.
Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer.Cancer. 2009 Nov 1;115(21):4946-58. doi: 10.1002/cncr.24564. Cancer. 2009. PMID: 19658179
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