Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas

Renata Dalla Costa; Brea Prindaville; Karen Wiss

doi:10.1111/pde.13407

Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas

Pediatr Dermatol. 2018 Mar;35(2):276-277. doi: 10.1111/pde.13407. Epub 2018 Jan 9.

Authors

Renata Dalla Costa¹, Brea Prindaville^{2

3}, Karen Wiss^{2

3}

Affiliations

¹ University of Massachusetts Medical School, Worcester, MA, USA.
² Departments of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.
³ Departments of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA.

PMID: 29315812
DOI: 10.1111/pde.13407

Abstract

Topical timolol maleate has recently gained popularity as a treatment for superficial infantile hemangiomas, but calculating a safe dose of timolol can be time consuming, which may limit the medication's use in fast-paced clinical environments. This report offers a simplified calculation of the maximum daily safe dosage as 1 drop of medication per kilogram of body weight.

Keywords: dosing; gel-forming solution, dose; infantile hemangioma; propranolol; timolol; timolol maleate.

MeSH terms

Administration, Topical
Adrenergic beta-Antagonists / administration & dosage*
Dose-Response Relationship, Drug
Drug Dosage Calculations*
Hemangioma / drug therapy*
Humans
Infant
Maximum Tolerated Dose
Timolol / administration & dosage*

Substances

Adrenergic beta-Antagonists
Timolol