What's in a Name? Cell Fate Reprogramming in Sarcomagenesis

Kevin B Jones

doi:10.1016/j.ccell.2017.12.005

What's in a Name? Cell Fate Reprogramming in Sarcomagenesis

Cancer Cell. 2018 Jan 8;33(1):5-7. doi: 10.1016/j.ccell.2017.12.005.

Author

Kevin B Jones¹

Affiliation

¹ Departments of Orthopaedics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Room 3726, Salt Lake City, UT 84112, USA. Electronic address: kevin.jones@hci.utah.edu.

PMID: 29316432
DOI: 10.1016/j.ccell.2017.12.005

Abstract

Differentiation features in cancer cells are typically attributed to the cell of origin. In this issue of Cancer Cell, Drummond et al. demonstrate a transdifferentiation program apparent in rhabdomyosarcomas (cancers with skeletal muscle differentiation features) arising through cell fate reprogramming from a single oncogene activation in endothelial cell precursors.

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MeSH terms

Cell Differentiation*
Cell Transdifferentiation*
Cellular Reprogramming
Humans
Sarcoma