Smoothened Sensor Places Sodium and Sterols Center Stage

Dev Cell. 2018 Jan 8;44(1):3-4. doi: 10.1016/j.devcel.2017.12.015. Epub 2018 Jan 8.

Abstract

Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.

Publication types

  • Comment

MeSH terms

  • Cholesterol
  • Hedgehog Proteins*
  • Receptors, G-Protein-Coupled
  • Signal Transduction
  • Smoothened Receptor
  • Sodium
  • Sterols*

Substances

  • Hedgehog Proteins
  • Receptors, G-Protein-Coupled
  • Smoothened Receptor
  • Sterols
  • Cholesterol
  • Sodium