Circadian Clocks and UPR: New Twists as the Story Unfolds

Nikolay B Milev; David Gatfield

doi:10.1016/j.devcel.2017.12.018

Circadian Clocks and UPR: New Twists as the Story Unfolds

Dev Cell. 2018 Jan 8;44(1):7-9. doi: 10.1016/j.devcel.2017.12.018. Epub 2018 Jan 8.

Authors

Nikolay B Milev¹, David Gatfield²

Affiliations

¹ Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne, Switzerland.
² Center for Integrative Genomics, University of Lausanne, Génopode, 1015 Lausanne, Switzerland. Electronic address: david.gatfield@unil.ch.

PMID: 29316442
DOI: 10.1016/j.devcel.2017.12.018

Abstract

Circadian clocks help control the unfolded protein response (UPR). In a recent issue of Nature Cell Biology, Bu et al. (2017) show that the interaction is reciprocal, with miRNA-211 providing a signal from the UPR to the clock component BMAL1, affecting circadian timing, global translational control, and cancer cell survival.

Publication types

Comment

MeSH terms

ARNTL Transcription Factors / genetics*
Circadian Clocks*
Circadian Rhythm
Humans
Protein Processing, Post-Translational
Unfolded Protein Response

Substances

ARNTL Transcription Factors