Circadian Clocks and UPR: New Twists as the Story Unfolds

Dev Cell. 2018 Jan 8;44(1):7-9. doi: 10.1016/j.devcel.2017.12.018. Epub 2018 Jan 8.


Circadian clocks help control the unfolded protein response (UPR). In a recent issue of Nature Cell Biology, Bu et al. (2017) show that the interaction is reciprocal, with miRNA-211 providing a signal from the UPR to the clock component BMAL1, affecting circadian timing, global translational control, and cancer cell survival.

Publication types

  • Comment

MeSH terms

  • ARNTL Transcription Factors / genetics*
  • Circadian Clocks*
  • Circadian Rhythm
  • Humans
  • Protein Processing, Post-Translational
  • Unfolded Protein Response


  • ARNTL Transcription Factors