Comparative evaluation of skin moisture after topical application of 10% and 30% lactobionic acid

J Cosmet Dermatol. 2018 Dec;17(6):1096-1100. doi: 10.1111/jocd.12485. Epub 2018 Jan 9.


Background: Dry skin is characterized by symptoms such as itching, redness, excessive exfoliation. These symptoms cause discomfort and contribute to secondary bacterial infections. Dry skin treatments are based on topical applications of various formulations. Among many of them are polyhydroxy acids, which recently gained more attention.

Aims: The aim of this study was a comparative assessment of hydration level (corneometric) after application of lactobionic acid (LA) in the form of peel at concentrations of 10% and 30%.

Material and methods: The study involved 10 Caucasian individuals aged 26-73 years. Eight treatments were performed at weekly intervals. The peels were applied using the "Split face" method-on the left side of the face 10% LA, and the right side 30% LA which consisted of specified concentration of LA, deionized water, xanthan gum, ethoxydiglycol. The test subjects received a 5% LA cream for overnight use. The cream consisted of deionized water, LA, isopropyl palmitate, ascorbyl palmitate, methylparaben. The products for this study were provided by Grehen Ltd. Celestynów, Poland. Prior to each procedure, the skin hydration level was measured using Corneometer CM 825 from Courage + Khazaka electronic GmbH.

Results: There was a statistically significant improvement in hydration level after 8 treatments for all measuring points and both concentrations. The difference of the skin hydration level between 10% LA and 30% LA could not be determined.

Conclusions: Lactobionic acid is a highly moisturizing agent. There was no significant difference in moisturizing effect between 10% LA concentration and 30% LA concentration.

Keywords: corneometer; lactobionic acid; skin moisture.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Disaccharides / administration & dosage
  • Disaccharides / pharmacology*
  • Face
  • Female
  • Humans
  • Male
  • Middle Aged
  • Skin / drug effects*


  • Disaccharides
  • lactobionic acid