In Vitro Validation of a Numerical Simulation of Leaflet Kinematics in a Polymeric Aortic Valve Under Physiological Conditions

Cardiovasc Eng Technol. 2018 Mar;9(1):42-52. doi: 10.1007/s13239-018-0340-7. Epub 2018 Jan 10.

Abstract

This paper describes a computational method to simulate the non-linear structural deformation of a polymeric aortic valve under physiological conditions. Arbitrary Lagrangian-Eulerian method is incorporated in the fluid-structure interaction simulation, and then validated by comparing the predicted kinematics of the valve's leaflets to in vitro measurements on a custom-made polymeric aortic valve. The predicted kinematics of the valve's leaflets was in good agreement with the experimental results with a maximum error of 15% in a single cardiac cycle. The fluid-structure interaction model presented in this study can simulate structural behaviour of a stented valve with flexible leaflets, providing insight into the haemodynamic performance of a polymeric aortic valve.

Keywords: Computational fluid dynamics; Fluid–structure interaction; Heart valves; In vitro experimental validation; Polymeric aortic valves.

Publication types

  • Validation Study

MeSH terms

  • Aortic Valve / physiology*
  • Biomechanical Phenomena
  • Computer Simulation*
  • Heart Valve Prosthesis Implantation / instrumentation*
  • Heart Valve Prosthesis*
  • Hemodynamics*
  • Humans
  • Materials Testing
  • Models, Cardiovascular*
  • Numerical Analysis, Computer-Assisted*
  • Polymers / metabolism*
  • Prosthesis Design
  • Reproducibility of Results

Substances

  • Polymers