Review
doi: 10.1038/s41594-017-0010-8.
Epub 2018 Jan 8.
Structural biology of Zika virus and other flaviviruses
Affiliations
- PMID: 29323278
- DOI: 10.1038/s41594-017-0010-8
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Review
Structural biology of Zika virus and other flaviviruses
Nat Struct Mol Biol.
2018 Jan.
Abstract
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.
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