Regulation of neuronal development and function by ROS

FEBS Lett. 2018 Mar;592(5):679-691. doi: 10.1002/1873-3468.12972. Epub 2018 Jan 26.


Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS-regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.

Keywords: NADPH oxidase; axon; cytoskeleton; dendrite; nervous system; neuronal polarity; pathfinding; plasticity; reactive oxygen species; synapse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics
  • Aging / metabolism
  • Aging / pathology
  • Animals
  • Growth Cones / metabolism*
  • Growth Cones / pathology
  • Humans
  • Nerve Net / metabolism*
  • Nerve Net / pathology
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology
  • Neurogenesis*
  • Reactive Oxygen Species / metabolism*
  • Synaptic Transmission*


  • Reactive Oxygen Species