Primary biliary cholangitis (PBC) is an immune-mediated cholestatic liver disease of unknown pathogenesis. The research on immunologic injury in the past helps us to understand more about this disease, but there are still many problems and challenges in the research on PBC. With a focus on the cholestatic features of PBC, this article reviews the research advances in bile acid metabolism in the field of PBC, in order to provide new thoughts for future research.
原发性胆汁性胆管炎（PBC）是一种免疫介导的肝内胆汁淤积性肝病，发病机制至今不清。既往在免疫损伤方面的研究，对认识该病提供了重要帮助，但PBC研究领域仍面临诸多的问题和挑战。现围绕PBC的胆汁淤积特征，重点综述了胆汁酸代谢在PBC研究领域的进展，以期为后续深入研究提供思路。.
Keywords: Bile acid; Metabolism; Primary biliary cholangitis; Therapy.