Toward Shorter Hospitalization After Endoscopic Transsphenoidal Pituitary Surgery: Day-by-Day Analysis of Early Postoperative Complications and Interventions

World Neurosurg. 2018 Mar:111:e871-e879. doi: 10.1016/j.wneu.2017.12.174. Epub 2018 Jan 8.


Background: It is unclear which patients have the greatest risk of developing complications in the first days after endoscopic transsphenoidal pituitary surgery (ETS) and how long patients should stay hospitalized after surgery. The objective of this study is to identify which patients are at risk for early postoperative medical and surgical reinterventions to optimize the length of hospitalization.

Methods: The medical records of 146 patients who underwent ETS for a pituitary adenoma between January 2013 and July 2016 were reviewed retrospectively. Data were collected on baseline patient-related characteristics, characteristics of the pituitary adenoma, perioperative complications and interventions, and postoperative outcomes. Patients who underwent additional interventions on days 2, 3, and 4 after ETS were identified as cases, and patients who did not have any interventions after day 1 postoperatively were identified as controls.

Results: Diabetes mellitus (odds ratio [OR], 4.279; 95% confidence interval [CI], 1.149-15.933; P = 0.03), incomplete adenoma resection (OR, 2.840; 95% CI, 1.228-6.568; P = 0.02) and increased morning sodium concentration on day 2 after surgery (OR, 5.211; 95% CI, 2.158-12.579; P <0.001) were associated with reinterventions. Patients without interventions on day 1 or 2 had only an 18.6% chance of a reintervention (OR, 0.201; 95% CI, 0.095-0.424).

Conclusions: Patients with diabetes mellitus, incomplete adenoma resection, and increased morning sodium concentration on day 2 after surgery have an increased chance on reinterventions. In addition, patients without any interventions on day 1 and 2 are at low risk for later reinterventions. These patients could be suitable candidates for early hospital discharge.

Keywords: Adenoma; Complication; Endoscopy; Length of hospital stay; Pituitary; Transsphenoidal.

MeSH terms

  • Adenoma / surgery
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Diabetes Complications / epidemiology
  • Endoscopy / methods*
  • Female
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Neurosurgical Procedures / methods*
  • Pituitary Gland / surgery*
  • Pituitary Neoplasms / surgery
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / therapy
  • Retrospective Studies
  • Risk Factors
  • Sodium / blood
  • Sphenoid Bone / surgery*
  • Survival Analysis
  • Young Adult


  • Sodium