Immunohistochemical analysis of IL-1 Receptor 1 in the discs of patients with temporomandibular joint dysfunction

Cranio. 2019 May;37(3):175-180. doi: 10.1080/08869634.2017.1417765. Epub 2018 Jan 12.


Objective Temporomandibular joint dysfunction (TMD) may affect a patient's quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD. Methods Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR (n = 12), and control group (n = 8). The samples were immunostained with IL-1R1 antibody and evaluated on both quantity and intensity of staining. Results There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining. Conclusion IL1-R1 was associated with ADDwR and ADDwoR in TMD discs of humans.

Keywords: TMJ; inflammation; interleukin 1.

MeSH terms

  • Humans
  • Joint Dislocations*
  • Magnetic Resonance Imaging
  • Quality of Life
  • Receptors, Interleukin-1
  • Temporomandibular Joint
  • Temporomandibular Joint Disc
  • Temporomandibular Joint Disorders*
  • Temporomandibular Joint Dysfunction Syndrome*


  • Receptors, Interleukin-1