The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials

High Blood Press Cardiovasc Prev. 2018 Mar;25(1):41-50. doi: 10.1007/s40292-018-0247-2. Epub 2018 Jan 12.


Introduction: Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial.

Aim: This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases.

Methods: Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI).

Results: A total of seventeen randomized controlled trials (684 participants) were included. Results showed that CoQ10 supplementation significantly decreased systolic blood pressure (SBP) (SMD - 0.30; 95% CI - 0.52, - 0.08). However, CoQ10 supplementation decreased diastolic blood pressure (DBP), but this was not statistically significant (SMD - 0.08; 95% CI - 0.46, 0.29).

Conclusions: CoQ10 supplementation may result in reduction in SBP levels, but did not affect DBP levels among patients with metabolic diseases. Additional prospective studies regarding the effect of CoQ10 supplementation on blood pressure in patients with metabolic diseases are necessary.

Keywords: Blood pressure; Coenzyme Q10; Meta-analysis; Metabolic diseases.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Aged
  • Blood Pressure / drug effects*
  • Dietary Supplements* / adverse effects
  • Evidence-Based Medicine
  • Female
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology
  • Hypertension / physiopathology*
  • Male
  • Metabolic Diseases / blood
  • Metabolic Diseases / diagnosis
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / epidemiology
  • Middle Aged
  • Odds Ratio
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Treatment Outcome
  • Ubiquinone / adverse effects
  • Ubiquinone / therapeutic use*


  • Ubiquinone