Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.)

Ann Nucl Med. 2018 Apr;32(3):217-235. doi: 10.1007/s12149-018-1230-7. Epub 2018 Jan 15.


Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown in this guideline are considered internationally useful as well. Only the original Japanese version is the formal document.

Keywords: Lu-177-DOTA-TATE; Neuroendocrine tumor; Radionuclide therapy.

MeSH terms

  • Health Personnel / education
  • Humans
  • Japan
  • Lutetium / chemistry
  • Lutetium / therapeutic use*
  • Manuals as Topic
  • Neuroendocrine Tumors / radiotherapy*
  • Nuclear Medicine / education
  • Nuclear Medicine / legislation & jurisprudence
  • Nuclear Medicine / methods
  • Practice Guidelines as Topic
  • Radiation Protection / methods
  • Radiopharmaceuticals / therapeutic use*
  • Safety


  • Radiopharmaceuticals
  • Lutetium