Chemical constituents from the flowers of Satsuma mandarin and their free radical scavenging and α-glucosidase inhibitory activities

Nat Prod Res. 2019 Jun;33(11):1670-1673. doi: 10.1080/14786419.2018.1425856. Epub 2018 Jan 15.

Abstract

Flowers of Citrus plants are used as mild sedatives and for the treatment of insomnia in traditional medicines. In Japan, tea made from the flowers of Satsuma mandarin is consumed as healthy drink. Hesperidin (1), hesperetin (2), rutin (3), quercetin (4), nicotiflorin (5), eriocitrin (6), narirutin (7), phenylethyl glucoside (8) and unshuoside A (9) were isolated from the MeOH extract of fresh flowers. Structure elucidation of these compounds was performed on the basis of NMR spectroscopic data. Among them, rutin (3), quercetin (4) and eriocitrin (6) showed potent free radical scavenging activity, whereas hesperetin (2) and quercetin (4) showed potent α-glucosidase inhibitory activity.

Keywords: Satsuma mandarin; Unshiu-mikan; flavonoids; flowers.

MeSH terms

  • Citrus / chemistry*
  • Drug Evaluation, Preclinical / methods
  • Flavonoids / analysis
  • Flavonoids / chemistry
  • Flowers / chemistry*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Glycoside Hydrolase Inhibitors / chemistry
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Hesperidin / analysis
  • Hesperidin / chemistry
  • Japan
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phenols / analysis
  • Phenols / chemistry
  • Plants, Medicinal / chemistry
  • Quercetin / analysis
  • Quercetin / chemistry
  • Rutin / analysis
  • Rutin / chemistry

Substances

  • Flavonoids
  • Free Radical Scavengers
  • Glycoside Hydrolase Inhibitors
  • Phenols
  • nicotiflorin
  • Rutin
  • Quercetin
  • Hesperidin
  • hesperetin