Adherence to antiretroviral therapy, stigma and behavioral risk factors in HIV-infected adolescents in Asia

AIDS Care. 2018 Jun;30(6):727-733. doi: 10.1080/09540121.2018.1425363. Epub 2018 Jan 16.

Abstract

We studied behavioral risks among HIV-infected and uninfected adolescents using an audio computer-assisted self-interview. A prospective cohort study was initiated between 2013 and 2014 in Malaysia, Thailand, and Vietnam. HIV-infected adolescents were matched to uninfected adolescents (4:1) by sex and age group (12-14 and 15-18 years). We enrolled 250 HIV-infected (48% male; median age 14.5 years; 93% perinatally infected) and 59 uninfected (51% male; median age 14.1 years) adolescents. At enrollment, HIV-infected adolescents were on antiretroviral therapy (ART) for a median (IQR) of 7.5 (4.7-10.2) years, and 14% had HIV-RNA >1000 copies/mL; 19% reported adherence <80%. Eighty-four (34%) HIV-infected and 26 (44%) uninfected adolescents reported having ever smoked cigarettes or drunk alcohol (p = 0.13); 10% of HIV-infected and 17% of uninfected adolescents reported having initiated sexual activity; 6 of the HIV-infected adolescents had HIV-RNA >1000 copies/mL. Risk behaviors were common among adolescents, with few differences between those with and without HIV.

Keywords: Asia; HIV; adherence; adolescents; stigma.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anti-HIV Agents / therapeutic use*
  • Case-Control Studies
  • Child
  • Female
  • HIV
  • HIV Infections / drug therapy*
  • HIV Infections / psychology*
  • Humans
  • Malaysia
  • Male
  • Medication Adherence*
  • Prospective Studies
  • Risk Factors
  • Risk-Taking*
  • Sexual Behavior
  • Social Stigma*
  • Thailand
  • Vietnam

Substances

  • Anti-HIV Agents