Deficit of Fat Free Mass in Very Preterm Infants at Discharge is Associated with Neurological Impairment at Age 2 Years

Anne Frondas-Chauty; Laure Simon; Cyril Flamant; Matthieu Hanf; Dominique Darmaun; Jean-Christophe Rozé

doi:10.1016/j.jpeds.2017.12.017

Deficit of Fat Free Mass in Very Preterm Infants at Discharge is Associated with Neurological Impairment at Age 2 Years

J Pediatr. 2018 May:196:301-304. doi: 10.1016/j.jpeds.2017.12.017. Epub 2018 Jan 11.

Authors

Anne Frondas-Chauty¹, Laure Simon², Cyril Flamant³, Matthieu Hanf⁴, Dominique Darmaun⁵, Jean-Christophe Rozé³

Affiliations

¹ Department of Neonatal Medicine, University Hospital of Nantes, Nantes, France; INRA UMR 1280, Physiologie des Adaptations Nutritionnelles, IMAD, CRNH Ouest, Nantes, France. Electronic address: anne.frondas@chu-nantes.fr.
² Department of Neonatal Medicine, University Hospital of Nantes, Nantes, France; INRA UMR 1280, Physiologie des Adaptations Nutritionnelles, IMAD, CRNH Ouest, Nantes, France.
³ Department of Neonatal Medicine, University Hospital of Nantes, Nantes, France; INRA UMR 1280, Physiologie des Adaptations Nutritionnelles, IMAD, CRNH Ouest, Nantes, France; INSERM CIC 1413, Clinical Investigation Center, Nantes University Hospital, Nantes, France.
⁴ INSERM CIC 1413, Clinical Investigation Center, Nantes University Hospital, Nantes, France; INSERM UMR 1181 Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Versailles Saint Quentin University, Villejuif, France.
⁵ INRA UMR 1280, Physiologie des Adaptations Nutritionnelles, IMAD, CRNH Ouest, Nantes, France; Nantes University, IMAD, Nantes, France.

PMID: 29336797
DOI: 10.1016/j.jpeds.2017.12.017

Abstract

Preterm infants have a deficit of fat-free mass accretion during hospitalization. This study suggests that z score of fat-free mass at discharge is associated with neurologic outcome (P = .003) at 2 years of age, independent of sex, gestational age, and birth weight z score. Interventions to promote quality of growth should be considered.

Keywords: body composition; deficit fat free mass; hospitalization; neurologic outcome; preterm.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Body Composition*
Child Development
Child, Preschool
Female
Humans
Infant
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature / growth & development*
Infant, Premature, Diseases / epidemiology
Infant, Premature, Diseases / etiology*
Infant, Very Low Birth Weight / growth & development*
Intensive Care Units, Neonatal
Male
Neurodevelopmental Disorders / epidemiology
Neurodevelopmental Disorders / etiology*
Patient Discharge
Plethysmography
Prospective Studies