Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 34 (4), 257-269

Defining B Cell Chromatin: Lessons From EBF1

Affiliations
Review

Defining B Cell Chromatin: Lessons From EBF1

Sören Boller et al. Trends Genet.

Abstract

Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

Keywords: B cell differentiation; Early B cell factor 1; chromatin; transcription factor network.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

MeSH terms

LinkOut - more resources

Feedback