Effect of transcranial direct current stimulation on short-term and long-term treatment of chronic tinnitus

Hamidreza Abtahi; Ahmadreza Okhovvat; Somaiie Heidari; Azar Gharagazarloo; Motahare Mirdamadi; Mohammad Hossein Nilforoush; Hossein Ghazavi

doi:10.1016/j.amjoto.2018.01.001

Effect of transcranial direct current stimulation on short-term and long-term treatment of chronic tinnitus

Am J Otolaryngol. 2018 Mar-Apr;39(2):94-96. doi: 10.1016/j.amjoto.2018.01.001. Epub 2018 Jan 6.

Authors

Hamidreza Abtahi¹, Ahmadreza Okhovvat¹, Somaiie Heidari¹, Azar Gharagazarloo¹, Motahare Mirdamadi¹, Mohammad Hossein Nilforoush², Hossein Ghazavi³

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
² Communication Disorders Research Center, Rehabilitation Sciences Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Otorhinolaryngology-Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: h.ghazavi@med.mui.ac.ir.

PMID: 29336898
DOI: 10.1016/j.amjoto.2018.01.001

Abstract

Objective: This study was conducted to investigate the effectiveness of anodal and cathodal methods in reducing the intensity of tinnitus and to compare them with the control.

Methodology: This randomized double-blind clinical trial with case and control groups was conducted in Al-Zahra Hospital in Isfahan between 2015 and 2016. In this trial, 51 patients with tinnitus, for at least one year, were selected among those outpatients visiting the throat, nose and ear clinic within this period. Inclusion criteria were patients on electrical stimulation prohibition, with Ménière's disease, otosclerosis, chronic headache, and pulsatile tinnitus. Patients were randomly divided in three equal-sized groups: anodal stimulation group, cathodal stimulation group, and control group. The subjects received 20-min current stimulation (2 mA). Five subjects were selected from those with a significant difference between the stimulated states (anodal or cathodal) and/or control. They received weekly transcranial electrical stimulation for two months, and their long-term recovery from tinnitus was investigated. Data analysis was done with SPSS20.

Results: Findings showed no significant between-groups difference in mean scores of tinnitus before the intervention (p = .68); whereas, this difference was significant immediately after the intervention (p = .02) and 1 h after it (p = .03). The mean score of tinnitus in the anodal stimulation group was significantly lower than the control; whereas, no significant difference was observed between the anodal and cathodal stimulation groups, and between the cathodal and control groups (p < .05). Findings also showed that the mean scores of tinnitus in two cathodal stimulation groups (p = .24) and control group (p = .62) were not significantly different at three different points of time; whereas, this score was significantly different in the anodal group at these time points (p = .01).

Conclusion: In conclusion, anodal stimulation was more effective than the cathodal and control stimulation in reducing the intensity of tinnitus in the short term.

Keywords: Anodal stimulation; Cathodal stimulation; Tinnitus; Transcranial direct current stimulation.

Publication types

Randomized Controlled Trial

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Audiometry
Chronic Disease
Double-Blind Method
Female
Follow-Up Studies
Hearing / physiology*
Humans
Male
Middle Aged
Retrospective Studies
Time Factors
Tinnitus / diagnosis
Tinnitus / therapy*
Transcranial Direct Current Stimulation / methods*
Treatment Outcome
Young Adult