Hemodynamic characteristics of hyperplastic remodeling lesions in cerebral aneurysms

PLoS One. 2018 Jan 16;13(1):e0191287. doi: 10.1371/journal.pone.0191287. eCollection 2018.

Abstract

Background & purpose: Hyperplastic remodeling (HR) lesions are sometimes found on cerebral aneurysm walls. Atherosclerosis is the results of HR, which may cause an adverse effect on surgical treatment for cerebral aneurysms. Previous studies have demonstrated that atherosclerotic changes had a correlation with certain hemodynamic characteristics. Therefore, we investigated local hemodynamic characteristics of HR lesions of cerebral aneurysms using computational fluid dynamics (CFD).

Methods: Twenty-four cerebral aneurysms were investigated using CFD and intraoperative video recordings. HR lesions and red walls were confirmed on the intraoperative images, and the qualification points were determined on the center of the HR lesions and the red walls. The qualification points were set on the virtual operative images for evaluation of wall shear stress (WSS), normalized WSS (NWSS), oscillatory shear index (OSI), relative residence time (RRT), and aneurysm formation indicator (AFI). These hemodynamic parameters at the qualification points were compared between HR lesions and red walls.

Results: HR lesions had lower NWSS, lower AFI, higher OSI and prolonged RRT compared with red walls. From analysis of the receiver-operating characteristic curve for hemodynamic parameters, OSI was the most optimal hemodynamic parameter to predict HR lesions (area under the curve, 0.745; 95% confidence interval, 0.603-0.887; cutoff value, 0.00917; sensitivity, 0.643; specificity, 0.893; P<0.01). With multivariate logistic regression analyses using stepwise method, NWSS was significantly associated with the HR lesions.

Conclusions: Although low NWSS was independently associated with HR lesions, OSI is the most valuable hemodynamic parameter to distinguish HR lesions from red walls.

MeSH terms

  • Aneurysm, Ruptured / pathology
  • Aneurysm, Ruptured / physiopathology
  • Aneurysm, Ruptured / surgery
  • Hemodynamics*
  • Humans
  • Intracranial Aneurysm / pathology*
  • Intracranial Aneurysm / physiopathology*
  • Intracranial Aneurysm / surgery
  • Intraoperative Period
  • Vascular Remodeling*

Grant support

The authors received no specific funding for this work.