Detection of mcr-4 positive S almonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016

Euro Surveill. 2018 Jan;23(2):17-00821. doi: 10.2807/1560-7917.ES.2018.23.2.17-00821.

Abstract

In this study we report the detection of the recently described mcr-4 gene in two human isolates of Salmonella enterica serovar Typhimurium. The strains were isolated from faecal samples of two Italian patients with gastroenteritis, collected in 2016. The identified mcr-4 genes (variant mcr-4.2) differed from the mcr-4 gene originally described in a Salmonella strain of swine origin from Italy. Salmonella species could represent a hidden reservoir for mcr genes.

Keywords: Italy; Salmonella enterica serovar Typhimurium; colistin resistance; human; mcr-4; mobile colistin resistance.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Colistin / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Feces / microbiology*
  • Gastroenteritis / diagnosis*
  • Gastroenteritis / microbiology
  • Genes, Bacterial
  • Humans
  • Italy
  • Microbial Sensitivity Tests
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / isolation & purification*
  • Sequence Analysis, DNA
  • Serogroup

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Colistin