T-cell lymphoma mimicking granulocytic sarcoma

Am J Clin Pathol. 1985 Dec;84(6):760-3. doi: 10.1093/ajcp/84.6.760.


A case of diffuse large cell lymphoma is described in which eosinophils and eosinophilic myelocytes were admixed with the neoplastic lymphoid cells. Because of the eosinophilic myelocytes, a diagnosis of granulocytic sarcoma was initially considered. No abnormalities of peripheral blood or bone marrow were found. Immunohistochemical studies of lymph node tissue demonstrated membrane antigens consistent with a lymphoma of helper T-cells. Small lymphoid cells with markedly irregular nuclei were present but rather inconspicuous among the larger lymphoid cells. Although a clinical remission was attained, the patient had a relapse with central nervous system involvement.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Biopsy
  • Bone Marrow / pathology
  • Diagnosis, Differential
  • Eosinophils / pathology*
  • Humans
  • Leukemia, Myeloid / diagnosis*
  • Leukemia, Myeloid / pathology
  • Lymph Nodes / pathology
  • Lymphoma / diagnosis*
  • Lymphoma / pathology
  • Male
  • Middle Aged
  • Skin / pathology
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Helper-Inducer / pathology


  • Antibodies, Monoclonal