Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr;19(4):213-228.
doi: 10.1038/nrm.2017.125. Epub 2018 Jan 17.

Shedding Light on the Cell Biology of Extracellular Vesicles


Shedding Light on the Cell Biology of Extracellular Vesicles

Guillaume van Niel et al. Nat Rev Mol Cell Biol. .


Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple physiological and pathological processes. Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material. Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis. However, in this expanding field, much remains unknown regarding the origin, biogenesis, secretion, targeting and fate of these vesicles.

Similar articles

See all similar articles

Cited by 419 articles

See all "Cited by" articles


    1. Small GTPases. 2017 Oct 2;8(4):220-232 - PubMed
    1. Biochim Biophys Acta. 2009 Dec;1793(12 ):1901-16 - PubMed
    1. J Cell Biol. 2006 Mar 13;172(6):923-35 - PubMed
    1. Blood. 2010 Jan 21;115(3):696-705 - PubMed
    1. Nat Commun. 2015 Jun 24;6:7506 - PubMed

Publication types

LinkOut - more resources