Liposomal Amphotericin B as Monotherapy in Relapsed Coccidioidal Meningitis

Ethan R Stewart; Matthew L Eldridge; Ian McHardy; Stuart H Cohen; George R Thompson 3rd

doi:10.1007/s11046-017-0240-7

Liposomal Amphotericin B as Monotherapy in Relapsed Coccidioidal Meningitis

Mycopathologia. 2018 Jun;183(3):619-622. doi: 10.1007/s11046-017-0240-7. Epub 2018 Jan 16.

Authors

Ethan R Stewart¹, Matthew L Eldridge¹, Ian McHardy², Stuart H Cohen¹, George R Thompson 3rd^{3

4}

Affiliations

¹ Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA, 95817, USA.
² Department of Medical Microbiology and Immunology, Department of Medicine, Division of Infectious Diseases, University of California - Davis, One Shields Ave, Tupper Hall, Rm 3138, Davis, CA, 95616, USA.
³ Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA, 95817, USA. grthompson@ucdavis.edu.
⁴ Department of Medical Microbiology and Immunology, Department of Medicine, Division of Infectious Diseases, University of California - Davis, One Shields Ave, Tupper Hall, Rm 3138, Davis, CA, 95616, USA. grthompson@ucdavis.edu.

PMID: 29340909
DOI: 10.1007/s11046-017-0240-7

Abstract

Coccidioidal meningitis remains a difficult clinical problem, and despite life-long therapy with triazole antifungals, relapses of disease and medication intolerance occur necessitating salvage treatment. We report two patients with recurrent coccidioidal meningitis who improved following a 2-week course of liposomal amphotericin B monotherapy and discuss potential advantages of this treatment option.

Keywords: Coccidioides; Coccidioidomycosis; Liposomal amphotericin B; Meningitis; Relapse.

Publication types

Case Reports

MeSH terms

Adult
Amphotericin B / administration & dosage*
Antifungal Agents / administration & dosage*
Coccidioidomycosis / drug therapy*
Humans
Male
Meningitis, Fungal / drug therapy*
Middle Aged
Recurrence
Treatment Outcome

Substances

Antifungal Agents
liposomal amphotericin B
Amphotericin B