Genetic and microbiome influence on lipid metabolism and dyslipidemia

Physiol Genomics. 2018 Feb 1;50(2):117-126. doi: 10.1152/physiolgenomics.00053.2017. Epub 2017 Dec 20.


Disruption in the metabolism of lipids is broadly classified under dyslipidemia and relates to the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic disease including obesity. Traditionally, the large interindividual variation has been related to genetic factors and diet. Genome-wide association studies have identified over 150 loci related to abnormal lipid levels, explaining ~40% of the total variation. Part of the unexplained variance has been attributed to environmental factors including diet, but the extent of the dietary contribution remains unquantified. Furthermore, other factors are likely to influence lipid metabolism including the gut microbiome, which plays an important role in the digestion of different dietary components including fats and polysaccharides. Here we describe the contributing role of host genetics and the gut microbiome to dyslipidemia and discuss the potential therapeutic implications of advances in understanding the gut microbiome to the treatment of dyslipidemia.

Keywords: diet; dyslipidemia; genetic; gut microbiome; lipid metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dyslipidemias / genetics*
  • Dyslipidemias / microbiology*
  • Gastrointestinal Microbiome / genetics
  • Gastrointestinal Microbiome / physiology*
  • Genome-Wide Association Study
  • Humans
  • Lipid Metabolism / genetics
  • Lipid Metabolism / physiology*
  • Polymorphism, Single Nucleotide / genetics