Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

Eur J Cancer Clin Oncol. 1985 Oct;21(10):1215-8. doi: 10.1016/0277-5379(85)90018-5.


Biologically active phi X174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-phi X174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

MeSH terms

  • Bacteriophage phi X 174 / drug effects*
  • DNA, Single-Stranded
  • DNA, Viral*
  • Etoposide / analogs & derivatives*
  • Etoposide / pharmacology
  • NADP / metabolism
  • Podophyllotoxin / analogs & derivatives*


  • DNA, Single-Stranded
  • DNA, Viral
  • NADP
  • Etoposide
  • Podophyllotoxin