Structural Insights in Multifunctional Papillomavirus Oncoproteins

Viruses. 2018 Jan 15;10(1):37. doi: 10.3390/v10010037.


Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species.

Keywords: NMR; X-ray; oncoproteins; papillomaviruses; structure; virus-host interactomics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Host-Pathogen Interactions
  • Humans
  • Nuclear Magnetic Resonance, Biomolecular
  • Oncogene Proteins, Viral / chemistry*
  • Papillomaviridae / chemistry*
  • Papillomavirus E7 Proteins / chemistry*
  • Protein Structure, Tertiary
  • Repressor Proteins / chemistry*


  • E6 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Repressor Proteins
  • protein E6, Bovine papillomavirus