Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet

Int J Mol Sci. 2018 Jan 15;19(1):254. doi: 10.3390/ijms19010254.


This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues of high-fructose diet (HFD)-induced diabetic rats. The previous results showed that orally administered GA (30 mg/kg body weight) for four weeks significantly reduced the levels of plasma glucose and triglyceride (TG) in HFD rats. GA also markedly decreased the perirenal adipose tissues weight of HFD rats in present study (p < 0.05). Western blot assay indicated that GA restored expression of insulin signaling-related proteins, such as insulin receptor (IR), protein kinase C-zeta (PKC-ζ), and glucose transporter-4 (GLUT4) in the perirenal adipose tissues of HFD rats. Moreover, GA enhanced expression of glycolysis-related proteins, such as phosphofructokinase (PFK) and pyruvate kinase (PK), and increased the expression of lipolysis-related proteins, such as adipose triglyceride lipase (ATGL), which is involved in lipolysis in the perirenal adipose tissues of HFD rats. This study revealed that GA may alleviate hypertriglyceridemia and fat accumulation through enhancing glycolysis and lipolysis pathways in perirenal adipose tissues of HFD rats. These findings also suggest the potential of GA in preventing the progression of diabetes mellitus (DM) complications.

Keywords: fat accumulation; gallic acid; high-fructose diet; hypertriglyceridemia; insulin signaling.

MeSH terms

  • Adipose Tissue / drug effects*
  • Adipose Tissue / metabolism*
  • Adiposity / drug effects*
  • Animals
  • Carbohydrate Metabolism / drug effects
  • Diabetes Mellitus, Experimental
  • Diet, High-Fat
  • Disease Models, Animal
  • Energy Metabolism / drug effects*
  • Fructose / metabolism
  • Gallic Acid / pharmacology*
  • Glycolysis / drug effects
  • Hypertriglyceridemia / etiology
  • Hypertriglyceridemia / metabolism*
  • Insulin / metabolism
  • Lipid Metabolism / drug effects
  • Lipolysis / drug effects
  • Metabolic Networks and Pathways / drug effects*
  • Rats
  • Signal Transduction / drug effects


  • Insulin
  • Fructose
  • Gallic Acid