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, 8 (6), 792-811

The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation


The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation

Wei Qin et al. Aging Dis.


Neural stem cells (NSCs) are special types of cells with the potential for self-renewal and multi-directional differentiation. NSCs are regulated by multiple pathways and pathway related transcription factors during the process of proliferation and differentiation. Numerous studies have shown that the compound medicinal preparations, single herbs, and herb extracts in traditional Chinese medicine (TCM) have specific roles in regulating the proliferation and differentiation of NSCs. In this study, we investigate the markers of NSCs in various stages of differentiation, the related pathways regulating the proliferation and differentiation, and the corresponding transcription factors in the pathways. We also review the influence of TCM on NSC proliferation and differentiation, to facilitate the development of TCM in neural regeneration and neurodegenerative diseases.

Keywords: Neural stem cells; differentiation; proliferation; traditional Chinese medicine.


Figure 1.
Figure 1.
Structures of Chinese herbal monomers

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    1. Bond AM, Bhalala OG, Kessler JA (2012). The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation. Dev Neurobiol, 72: 1068-1084. - PMC - PubMed
    1. Ming GL, Song H (2011). Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron, 70: 687-702. - PMC - PubMed
    1. Bamba Y, Shofuda T, Kanematsu D, Nonaka M, Yamasaki M, Okano H, et al. (2014). Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics. Biochem Biophys Res Commun, 447: 683-688. - PubMed
    1. Cheng F, Lu XC, Hao HY, Dai XL, Qian TD, Huang BS, et al. (2014). Neurogenin 2 converts mesenchymal stem cells into a neural precursor fate and improves functional recovery after experimental stroke. Cell Physiol Biochem, 33: 847-858. - PubMed
    1. Kozhich OA, Hamilton RS, Mallon BS (2013). Standardized generation and differentiation of neural precursor cells from human pluripotent stem cells. Stem Cell Rev, 9: 531-536. - PMC - PubMed

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