Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative

Future Oncol. 2018 Feb;14(4):363-378. doi: 10.2217/fon-2017-0410. Epub 2018 Jan 18.


Aim: To characterize the clinical indications of females (<15 years old) undergoing ovarian tissue cryopreservation (OTC) through the Oncofertility Consortium's National Physicians Cooperative (OC-NPC).

Patients & methods: The clinical indications of 114 females who underwent OTC were classified, and their incidence was compared with childhood cancer databases.

Results: Leukemias/myeloproliferative diseases/myelodysplastic diseases and hemoglobinopathies were the most prevalent oncologic and nononcologic indications for OTC, respectively. The frequencies of malignant bone tumors and soft tissue and other extraosseous sarcomas were higher in the OC-NPC cohort relative to the general population, while CNS/intracranial/intraspinal neoplasms, retinoblastoma and hepatic tumors were lower.

Conclusion: Those opting for OTC through the OC-NPC are at highest fertility risk, indicating that the appropriate patient populations are being identified. [Formula: see text].

Keywords: childhood cancer; fertility preservation; oncofertility; ovarian tissue cryopreservation; pediatric; women's health.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cryopreservation / methods
  • Female
  • Fertility Preservation / methods*
  • Humans
  • Laparoscopy
  • Neoplasms / epidemiology*
  • Neoplasms / physiopathology
  • Ovary / physiology*