Analgesic properties of enkephalinase inhibitors: animal and human studies

Prog Clin Biol Res. 1985;192:363-70.

Abstract

D-phenylalanine, bacitracin and puromycin produce long-lasting, naloxone-reversible analgesia in mice. Analgesic potency parallels potency of these compounds as inhibitors of met-enkephalin degradation by mouse brain enzymes. D-phenylalanine potentiates acupuncture analgesia in mice and humans and has been used to ameliorate a variety of human chronic pain conditions.

Publication types

  • Comparative Study

MeSH terms

  • Acupuncture Therapy
  • Analgesia
  • Analgesics*
  • Animals
  • Bacitracin / pharmacology*
  • Brain / enzymology
  • Drug Synergism
  • Endorphins / metabolism
  • Enkephalin, Methionine / pharmacology
  • Humans
  • Kinetics
  • Mice
  • Naloxone / pharmacology
  • Neprilysin
  • Pain, Intractable / therapy
  • Phenylalanine / pharmacology*
  • Protease Inhibitors*
  • Puromycin / pharmacology*
  • Stereoisomerism
  • beta-Endorphin

Substances

  • Analgesics
  • Endorphins
  • Protease Inhibitors
  • Bacitracin
  • Naloxone
  • Phenylalanine
  • Puromycin
  • Enkephalin, Methionine
  • beta-Endorphin
  • Neprilysin