Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H839-H852. doi: 10.1152/ajpheart.00409.2017. Epub 2017 Dec 22.

Abstract

Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Recent research has indicated that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD+-boosting strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease are surveyed.

Keywords: cardiovascular diseases; ischemia-reperfusion; nicotinamide adenine dinucleotide; oxidation-reduction (redox).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Agents / adverse effects
  • Cardiovascular Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Dietary Supplements* / adverse effects
  • Energy Metabolism / drug effects*
  • Humans
  • Myocytes, Cardiac / drug effects*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology
  • NAD / adverse effects
  • NAD / metabolism*
  • NAD / therapeutic use*
  • Oxidation-Reduction
  • Signal Transduction / drug effects

Substances

  • Cardiovascular Agents
  • NAD