RNA helicases in RNA decay

Biochem Soc Trans. 2018 Feb 19;46(1):163-172. doi: 10.1042/BST20170052. Epub 2018 Jan 19.

Abstract

RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases. Whereas bacterial degradosomes are associated with RNA helicases from the DEAD-box family, the exosomes and mitochondrial degradosome use the help of Ski2-like and Suv3 RNA helicases.

Keywords: RNA decay; RNA helicases; degradosome; exosome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism
  • DEAD-box RNA Helicases / metabolism*
  • Endoribonucleases / metabolism
  • Exosomes / enzymology
  • Exosomes / metabolism
  • Mitochondria / enzymology
  • Mitochondria / metabolism
  • Multienzyme Complexes / metabolism
  • Polyribonucleotide Nucleotidyltransferase / metabolism
  • RNA / chemistry
  • RNA / metabolism*
  • RNA Helicases / metabolism
  • RNA Stability*

Substances

  • Multienzyme Complexes
  • degradosome
  • RNA
  • Polyribonucleotide Nucleotidyltransferase
  • Endoribonucleases
  • DEAD-box RNA Helicases
  • RNA Helicases