Cryptococcus gattii genotype VGIIa infection imported from Vancouver Island to Japan

J Infect Chemother. 2018 Jul;24(7):573-575. doi: 10.1016/j.jiac.2017.12.014. Epub 2018 Jan 17.


A 71-year-old Japanese man with travel history to the Vancouver Island, Canada was diagnosed the pulmonary and central nervous system infections caused by Cryptococcus gattii genotype VGIIa. This is the first imported case of Cryptococcus gattii genotype VGIIa infection from endemic area of North America to Japan. He was recovery with no residual neurological dysfunction by early resection of brain mass and antifungal therapy. Early surgical resection of cerebellar cryptococcoma may shorten the length of induction therapy with antifungal drugs.

Keywords: Cryptococcosis; Cryptococcus gattii; Japan; Surgery; Travel; Vancouver Island.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / therapeutic use
  • Antigens, Fungal / blood
  • Antigens, Fungal / cerebrospinal fluid
  • Canada
  • Central Nervous System Fungal Infections / drug therapy
  • Central Nervous System Fungal Infections / microbiology*
  • Central Nervous System Fungal Infections / surgery
  • Computed Tomography Angiography
  • Cryptococcosis / drug therapy
  • Cryptococcosis / microbiology*
  • Cryptococcus gattii / classification
  • Cryptococcus gattii / genetics*
  • Cryptococcus gattii / isolation & purification
  • Genotype
  • Humans
  • Japan
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / microbiology*
  • Magnetic Resonance Imaging
  • Male
  • Multilocus Sequence Typing
  • Radiography
  • Sequence Analysis, DNA


  • Antifungal Agents
  • Antigens, Fungal