Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 5;8:1825.
doi: 10.3389/fimmu.2017.01825. eCollection 2017.

Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

Free PMC article

Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

Locke D Uppendahl et al. Front Immunol. .
Free PMC article


Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.

Keywords: cervical cancer; gynecologic malignancy; immunotherapy; natural killer cells; ovarian cancer.


Figure 1
Figure 1
Illustration of NK cell interaction with tumor cells, as well as NK influence on T cell differentiation.

Similar articles

See all similar articles

Cited by 5 articles


    1. Herberman RB, Nunn ME, Holden HT, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer (1975) 16(2):230–9.10.1002/ijc.2910160204 - DOI - PubMed
    1. Kiessling R, Klein E, Pross H, Wigzell H. “Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur J Immunol (1975) 5(2):117–21.10.1002/eji.1830050209 - DOI - PubMed
    1. Ljunggren HG, Malmberg KJ. Prospects for the use of NK cells in immunotherapy of human cancer. Nat Rev Immunol (2007) 7(5):329–39.10.1038/nri2073 - DOI - PubMed
    1. Knorr DA, Bachanova V, Verneris MR, Miller JS. Clinical utility of natural killer cells in cancer therapy and transplantation. Semin Immunol (2014) 26(2):161–72.10.1016/j.smim.2014.02.002 - DOI - PMC - PubMed
    1. Lanier LL, Phillips JH, Hackett J, Jr, Tutt M, Kumar V. Natural killer cells: definition of a cell type rather than a function. J Immunol (1986) 137(9):2735–9. - PubMed

LinkOut - more resources