Renal physiology: TRPC5 inhibition to treat progressive kidney disease

Nat Rev Nephrol. 2018 Mar;14(3):145-146. doi: 10.1038/nrneph.2018.4. Epub 2018 Jan 22.

Authors

Jenny van der Wijst¹, René J M Bindels¹

Affiliation

¹ Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

PMID: 29355170
DOI: 10.1038/nrneph.2018.4

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Glomerulosclerosis, Focal Segmental / drug therapy*
Glomerulosclerosis, Focal Segmental / genetics
Hypertension, Renal / drug therapy*
Indazoles / pharmacology*
Mutation
Podocytes / drug effects
Proteinuria / drug therapy*
Rats
Rats, Inbred Dahl
Rats, Transgenic
Small Molecule Libraries
TRPC Cation Channels / antagonists & inhibitors*
TRPC Cation Channels / pharmacology
rac1 GTP-Binding Protein / genetics

Substances

AC1903
Indazoles
Small Molecule Libraries
TRPC Cation Channels
Trpc5 protein, rat
Rac1 protein, rat
rac1 GTP-Binding Protein