Renal Functions of TRP Channels in Health and Disease

In: Neurobiology of TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2017. Chapter 10.


One key function of the kidneys is the ultrafiltration of plasma by the renal glomeruli in order to dispose of metabolic end products and excess electrolytes. However, in order to maintain body electrolyte homeostasis, the vast majority of filtrated salts and water are reabsorbed along the different segments of the renal tubular system. For instance, approximately 80% of total serum Mg2+ is filtered in the glomeruli with more than 95% being reabsorbed along the nephron. A vast array of ion channels and transporters is known to be involved in the filtration, secretion, and reabsorption of electrolytes.

Publication types

  • Review