Myocardial hypertrophy in rats with renal insufficiency

Kidney Int. 1985 Nov;28(5):775-82. doi: 10.1038/ki.1985.197.

Abstract

Increased defatted dry wt of the heart and increased heart calcium content were observed in subtotally nephrectomized male Sprague-Dawley rats compared with sham-operated pairfed controls. Increased heart wt contrasted with no change of the weight of viscera (liver, spleen) and markedly decreased weight of striated muscle. Heart wt was unchanged after 5 days of renal insufficiency, but significantly increased after 14 or 21 days. Increased heart wt persisted despite effective beta adrenoreceptor blockade (2 X 10 mg metroprolol/kg/day i.p.) or effective alpha-1-adrenoreceptor blockade (2 X 2 mg prazosin/kg/day i.p.). Increased heart wt was also demonstrable despite normalization of basal blood pressure (intraarterial blood pressure measurement in conscious animals): blood pressure was lowered in one series with hydralazine/nadolol in drinking water (calculated to deliver 20 and 2 mg/kg/day, respectively) and in another series with furosemide in drinking water (15 mg/kg/day) combined with metoprolol (2 X 10 mg/kg/day i.p.). Increased heart wt was also noted despite correction of anemia by blood transfusion (Hct greater than 40%) and after parathyroidectomy in animals kept eucalcemic with high dietary calcium. Micromorphometry of left ventricular myocardium in perfusion-fixed tissue showed no significant change of the relative proportion of connective tissue and myocardial fibers. Myocardial isomyosin pattern was changed with an increase of fast-migrating V1 isomyosin in animals with renal insufficiency compared to sham-operated pairfed controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Animals
  • Blood Pressure
  • Blood Transfusion
  • Calcium / antagonists & inhibitors
  • Calcium / metabolism
  • Cardiomegaly / etiology*
  • Cardiomegaly / metabolism
  • Cardiomegaly / pathology
  • Hydralazine / pharmacology
  • Isoenzymes / metabolism
  • Kidney Diseases / complications*
  • Kidney Diseases / etiology
  • Male
  • Metoprolol / pharmacology
  • Microscopy, Electron
  • Myocardium / metabolism
  • Myocardium / pathology
  • Myosins / metabolism
  • Nadolol
  • Nephrectomy
  • Organ Size / drug effects
  • Parathyroid Glands / physiology
  • Prazosin / pharmacology
  • Propanolamines / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Trifluoperazine / pharmacology

Substances

  • Isoenzymes
  • Propanolamines
  • Trifluoperazine
  • Hydralazine
  • Nadolol
  • Adenosine Triphosphatases
  • Myosins
  • Metoprolol
  • Calcium
  • Prazosin