Long-term Exposure to Fine Particulate Matter Air Pollution and Type 2 Diabetes Mellitus in Elderly: A Cohort Study in Hong Kong

Environ Int. 2018 Apr;113:350-356. doi: 10.1016/j.envint.2018.01.008. Epub 2018 Feb 1.

Abstract

Background: Evidence for the link between long-term air pollution exposure and occurrence of diabetes is limited and the results are mixed.

Objectives: We aimed to assess the association of long-term residential exposure to fine particulate matter (PM2.5) with the prevalence and incidence of type 2 diabetes mellitus (DM).

Methods: This is a prospective cohort study. We studied 61,447 participants of the Chinese Elderly Health Services cohort in Hong Kong enrolled 1998-2001 and followed participants without DM at baseline to 31 December 2010 to ascertain the first hospital admissions for type 2 DM. Yearly mean residential PM2.5 exposure was predicted based on satellite data. Logistic regression and time-varying Cox regression model were used to evaluate the prevalence and incidence risk of DM associated with PM2.5 while adjusting for potential individual and neighborhood confounders.

Results: There were 61,447 participants included in the study of prevalent DM, and in 53,905 participants without DM at baseline we studied incident type 2 DM. Over a mean follow-up of 9.8 years, we ascertained 806 incident cases of type 2 DM. After adjusting for potential confounders, the odds ratio (OR) for every interquartile range (3.2 μg/m3) increase of PM2.5 concentration was 1.06 (95% confidence interval (CI): 1.01-1.11) for prevalent DM, while the corresponding hazard ratio (HR) was 1.15 (95% CI: 1.05-1.25) for incident type 2 DM.

Conclusions: Long-term exposure to high levels of PM2.5 may increase the risk of both prevalence and incidence of type 2 diabetes mellitus in Hong Kong elderly population.

Keywords: Cohort study; Fine particulate matter; Incidence; Long-term residential exposure; Prevalence; Type 2 diabetes.

MeSH terms

  • Aged
  • Air Pollutants
  • Air Pollution / adverse effects*
  • Air Pollution / analysis
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / etiology*
  • Environmental Exposure / adverse effects*
  • Environmental Exposure / analysis
  • Female
  • Hong Kong / epidemiology
  • Humans
  • Incidence
  • Male
  • Particulate Matter / adverse effects*
  • Particulate Matter / analysis
  • Prevalence
  • Proportional Hazards Models
  • Prospective Studies
  • Risk

Substances

  • Air Pollutants
  • Particulate Matter