Caveolins as Regulators of Stress Adaptation

Mol Pharmacol. 2018 Apr;93(4):277-285. doi: 10.1124/mol.117.111237. Epub 2018 Jan 22.


Caveolins have been recognized over the past few decades as key regulators of cell physiology. They are ubiquitously expressed and regulate a number of processes that ultimately impact efficiency of cellular processes. Though not critical to life, they are central to stress adaptation in a number of organs. The following review will focus specifically on the role of caveolin in stress adaptation in the heart, brain, and eye, three organs that are susceptible to acute and chronic stress and that show as well declining function with age. In addition, we consider some novel molecular mechanisms that may account for this stress adaptation and also offer potential to drive the future of caveolin research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Animals
  • Caveolins / metabolism*
  • Cell Death / physiology
  • Cell Physiological Phenomena / physiology*
  • Cell Proliferation / physiology
  • Humans
  • Oxidative Stress / physiology
  • Stress, Physiological / physiology*


  • Caveolins