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Review
. 2018 Jan/Feb;24(1):36-40.
doi: 10.1097/PPO.0000000000000296.

Toxicities Associated With PD-1/PD-L1 Blockade

Daniel Y Wang  1 , Douglas B Johnson, Elizabeth J Davis
Affiliations
Free PMC article
Review

Toxicities Associated With PD-1/PD-L1 Blockade

Daniel Y Wang et al. Cancer J. 2018 Jan/Feb.
Free PMC article

Abstract

Immune checkpoint inhibitors, particularly those targeting PD-1/PD-L1, produce durable responses in a subset of patients across cancer types. Although often well tolerated, these agents can induce a broad spectrum of autoimmune-like complications that may affect any organ system. Treatment of these toxicities primarily consists of immune suppression with corticosteroids and other agents. This review briefly discusses the mechanisms of immune-related adverse events, overviews the clinical and pathologic features of major toxicities caused by PD-1/PD-L1 blockade, and reviews their management.

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Conflict of interest statement

Conflicts of interest: DBJ serves on advisory boards for BMS, Genoptix, Incyte, Merck, and Novartis, and receives research-related funding from Incyte.

Figures

Figure 1
Figure 1
Approximate incidence of immune-related adverse events with anti-PD-1 monotherapy
Figure 2
Figure 2
Algorithm for management of common irAEs (pneumonitis, diarrhea/colitis, hepatitis). *Hospitalization may not be required for ambulatory, well-hydrated patients available for close outpatient follow-up
See this image and copyright information in PMC

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