Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms

BMC Complement Altern Med. 2018 Jan 24;18(1):26. doi: 10.1186/s12906-018-2099-7.


Background: Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim was to evaluate the effects of the administration of Garcinia cambogia (GC) and Glucomannan (GNN) on long-term weight loss in people with overweight or obesity.

Methods: Prospective, not-randomized controlled intervention trial was conducted. We treated 214 subjects with overweight or obesity with GC and GNN (500 mg twice a day, each) for 6 months evaluating weight, fat mass, visceral fat, basal metabolic rate, and lipid and glucose blood profiles comparing them with basal values. Some patients were carriers of polymorphisms PLIN4 -11482G > A-, fat mass and obesity-associated (FTO) -rs9939609 A/T- and β-adrenergic receptor 3 (ADRB3) -Trp64Arg.

Results: Treatment produced weight loss, reducing fat mass, visceral fat, lipid and blood glucose profiles while increasing basal metabolic rate. Results were independent of sex, age or suffering from hypertension, diabetes mellitus type 2 or dyslipidemia and were attenuated in carriers of PLIN4, FTO, Trp64Arg polymorphisms.

Conclusions: Administration of GC and GNN reduce weight and improve lipid and glucose blood profiles in people with overweight or obesity, although the presence of polymorphisms PLIN4, FTO and ADRB3 might hinder in some degree these effects. ISRCTN78807585, 19 September 2017, retrospective study.

Keywords: Obesity; Overweight; Polymorphisms.

MeSH terms

  • Adult
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics*
  • Amorphophallus / chemistry
  • Female
  • Garcinia cambogia*
  • Humans
  • Male
  • Mannans* / pharmacology
  • Mannans* / therapeutic use
  • Obesity* / drug therapy
  • Obesity* / epidemiology
  • Obesity* / genetics
  • Perilipin-4 / genetics*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Polymorphism, Genetic / genetics
  • Prospective Studies
  • Receptors, Adrenergic, beta-3 / genetics*
  • Weight Loss* / drug effects
  • Weight Loss* / genetics


  • ADRB3 protein, human
  • Mannans
  • PLIN4 protein, human
  • Perilipin-4
  • Plant Extracts
  • Receptors, Adrenergic, beta-3
  • (1-6)-alpha-glucomannan
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human