Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy

Obesity (Silver Spring). 2018 Feb;26(2):332-339. doi: 10.1002/oby.22094.


Objective: This study evaluated the effect of lorcaserin 10 mg twice daily (LOR BID), or with phentermine 15 mg once daily (LOR BID + PHEN QD) and 15 mg twice daily (LOR BID + PHEN BID), in conjunction with energy restriction on food cravings.

Methods: Two hundred and thirty-five patients without diabetes but with obesity or overweight and ≥ 1 comorbidity received LOR BID, LOR BID + PHEN QD, or LOR BID + PHEN BID for 12 weeks in a randomized double-blind study. The Food Craving Inventory (FCI) and the Control of Eating Questionnaire (COEQ) were administered over 12 weeks.

Results: The FCI total score and the subscale scores reduced from baseline in all groups. The least squares means (95% confidence intervals) for the total scores were -0.65 (-0.75 to -0.55), -0.75 (-0.84 to -0.65), and -0.84 (-0.95 to -0.74) in the LOR BID, LOR BID + PHEN QD, and LOR BID + PHEN BID groups, respectively. Cravings assessed by COEQ reduced from baseline in all groups. In general, the combination treatments were more effective than lorcaserin alone. At week 12, except for fruit juice and dairy products, general and specific cravings reduced in LOR BID + PHEN BID compared with LOR BID (P < 0.05).

Conclusions: Lorcaserin in combination with phentermine improves control of food cravings during short-term energy restriction.

Trial registration: ClinicalTrials.gov NCT01987427.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Obesity Agents / pharmacology
  • Anti-Obesity Agents / therapeutic use
  • Benzazepines / pharmacology
  • Benzazepines / therapeutic use*
  • Craving / drug effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity / drug therapy*
  • Overweight / drug therapy*
  • Phentermine / pharmacology
  • Phentermine / therapeutic use*
  • Young Adult


  • Anti-Obesity Agents
  • Benzazepines
  • lorcaserin
  • Phentermine

Associated data

  • ClinicalTrials.gov/NCT01987427