From haematopoietic stem cells to complex differentiation landscapes

Nature. 2018 Jan 24;553(7689):418-426. doi: 10.1038/nature25022.


The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / cytology
  • Animals
  • Cell Cycle
  • Cell Lineage
  • Cell Self Renewal
  • Gene Expression Profiling
  • Hematologic Diseases / therapy
  • Hematopoiesis* / genetics
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Multipotent Stem Cells / cytology
  • Single-Cell Analysis