Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

Exp Clin Endocrinol Diabetes. 2019 May;127(5):311-319. doi: 10.1055/s-0043-124183. Epub 2018 Jan 24.

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a disease associated with increased oxidative stress which results from mitochondrial dysfunction. Coenzyme Q10 (CoQ10) is an essential antioxidant for energy production in mitochondria. The purpose of this randomized double-blind clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of gamma-glutamyl transferase (GGT), pseudocholinesterase (PchE), bilirubin, ferritin, and high-sensitivity c-reactive protein (hs-CRP) and metabolic syndrome biomarkers in women with T2DM.

Material & methods: Eighty women with T2DM enrolled in this study. Thirty six of them were randomized in the drug group (receiving 100 mg/day of CoQ10) and 44 women were randomized in placebo group. Intervention was continued for 12 weeks. In both groups 35 subjects finished the study and were included in the analysis. Serum levels of the variables were measured before and after supplementation.

Results: Serum values of FBS (P=0.039), HOMA-IR (P=0.01), ferritin (P<0.001), total cholesterol (TC) (P=0.006), LDL-C (P=0.007) decreased and HDL-C (P=0.02) increased significantly in the drug group after intervention. Serum levels of triglyceride (P=0.09) decreased marginally in CoQ10 group.

Conclusions: The results of the current study had shown that after supplementation with 100 mg/day of CoQ10 for 12 weeks, serum values of FBS, HOMA-IR, TC, LDL-C and ferritin were decreased and values of HDL-C were increased in women with T2DM.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bilirubin / blood*
  • Blood Glucose / drug effects*
  • Butyrylcholinesterase / blood
  • Butyrylcholinesterase / drug effects*
  • C-Reactive Protein / drug effects*
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / drug effects*
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / drug effects*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dietary Supplements
  • Female
  • Ferritins / blood
  • Ferritins / drug effects*
  • Humans
  • Middle Aged
  • Treatment Outcome
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology
  • gamma-Glutamyltransferase / blood
  • gamma-Glutamyltransferase / drug effects

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Ubiquinone
  • C-Reactive Protein
  • Ferritins
  • gamma-Glutamyltransferase
  • Butyrylcholinesterase
  • coenzyme Q10
  • Bilirubin