Comparative effects of oxygen, nifedipine and ketanserin in hypoxic pulmonary hypertension

Cor Vasa. 1985;27(6):406-11.


The authors measured changes in pulmonary and systemic haemodynamics in seven patients following oxygen inhalation, nifedipine and Ketanserin administration. A significant decrease in mean pulmonary artery pressure, cardiac index and heart rate could be observed following 30-min oxygen inhalation. No significant changes were found in pulmonary haemodynamics 1 hour after sublingual administration of 20 mg Corinfar (nifedipine). Long-term treatment (6 months) with Corinfar (30-60 mg per day) was not followed by a significant change in mean pulmonary artery pressure. However, in 3 patients a decrease in mean pulmonary artery pressure (6-11 mmHg) could be observed. Ketanserin (10 mg intravenously) did not significantly change the mean pulmonary artery pressure in patients with hypoxic pulmonary hypertension.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Carbon Dioxide / blood
  • Cardiac Output / drug effects
  • Female
  • Heart Rate / drug effects
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypoxia / drug therapy*
  • Ketanserin
  • Lung Diseases, Obstructive / drug therapy
  • Lung Volume Measurements
  • Male
  • Middle Aged
  • Nifedipine / therapeutic use*
  • Oxygen / blood
  • Oxygen Inhalation Therapy*
  • Piperidines / therapeutic use*
  • Pulmonary Wedge Pressure / drug effects
  • Serotonin Antagonists / therapeutic use*


  • Piperidines
  • Serotonin Antagonists
  • Carbon Dioxide
  • Ketanserin
  • Nifedipine
  • Oxygen