Effects of Multivitamin, Multimineral and Phytonutrient Supplementation on Nutrient Status and Biomarkers of Heart Health Risk in a Russian Population: A Randomized, Double Blind, Placebo Controlled Study

Nutrients. 2018 Jan 25;10(2):120. doi: 10.3390/nu10020120.


The primary objective of this clinical study was to evaluate the effect of a dietary multivitamin, multimineral and phytonutrient (VMP) supplement on blood nutrient status and biomarkers of heart health risk in a Russian population. One hundred twenty healthy adults (40-70 years) were recruited for a 56-day (eight-week) randomized, double blind, placebo controlled study with parallel design. Subjects were divided into two groups and received either a VMP or a placebo (PLA) supplement. Blood nutrient levels of β-carotene, α-tocopherol, vitamin C, B6, B12, red blood cell (RBC) folate, Zinc and Selenium were measured at baseline and on Days 28 and 56, and quercetin was measured at baseline and on Day 56. Blood biomarkers of heart health, i.e. homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL), gamma-glutamyl transferase (GGT), uric acid and blood lipid profile, were measured at baseline and Day 56. Dietary VMP supplementation for 56 days significantly increased circulating levels of quercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status. Both serum Hcy and GGT were significantly reduced (-3.97 ± 10.09 µmol/L; -1.68 ± 14.53 U/L, respectively) after VMP supplementation compared to baseline. Dietary VMP supplementation improved the nutrient status and reduced biomarkers of heart health risk in a Russian population.

Keywords: dietary supplementation; heart health risk; homocysteine; multimineral; multivitamin; nutrient status; phytonutrient; quercetin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood*
  • Body Mass Index
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / epidemiology*
  • Cholesterol / blood
  • Diet
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Homocysteine / blood
  • Humans
  • Male
  • Middle Aged
  • Nutritional Status*
  • Phytochemicals / administration & dosage*
  • Phytochemicals / blood
  • Russia
  • Trace Elements / administration & dosage*
  • Trace Elements / blood
  • Triglycerides / blood
  • Uric Acid / blood
  • Vitamins / administration & dosage*
  • Vitamins / blood
  • gamma-Glutamyltransferase / blood


  • Biomarkers
  • Phytochemicals
  • Trace Elements
  • Triglycerides
  • Vitamins
  • Homocysteine
  • Uric Acid
  • C-Reactive Protein
  • Cholesterol
  • gamma-Glutamyltransferase