Association of ambulatory blood pressure variability with coronary artery calcium

J Clin Hypertens (Greenwich). 2018 Feb;20(2):289-296. doi: 10.1111/jch.13171. Epub 2018 Jan 25.


Blood pressure (BP) variability is associated with progression to clinical atherosclerosis. The evidence is inconclusive if BP variability predicts cardiovascular outcomes in low-risk populations. The aim of this study was to analyze the association of 24-hour BP variability with coronary artery calcium (CAC) among a group of individuals without coronary artery disease. The Masked Hypertension Study targeted patients with borderline high BP (120-149 mm Hg systolic and/or 80-95 mm Hg diastolic). Ambulatory blood pressure monitoring (ABPM) was performed at two time-points, 8 days apart. CAC was measured at exit visit via cardiac CT and reported as Agatston Score. Weighted standard deviations and average real variability were calculated from ABPM. Of the 322 participants who underwent cardiac CT, 26% (84) had CAC present, 52% (168) were female, and 21% (64) were black. BP variability did not differ by CAC group. In this low cardiovascular risk group, CAC was not associated with 24-hour ambulatory BP variability.

Keywords: ambulatory blood pressure; blood pressure monitoring; blood pressure variability; coronary artery calcium.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Blood Pressure / physiology
  • Blood Pressure Monitoring, Ambulatory / methods*
  • Calcium* / analysis
  • Calcium* / metabolism
  • Coronary Artery Disease* / diagnosis
  • Coronary Artery Disease* / metabolism
  • Coronary Vessels* / diagnostic imaging
  • Coronary Vessels* / metabolism
  • Correlation of Data
  • Female
  • Humans
  • Male
  • Masked Hypertension* / diagnosis
  • Masked Hypertension* / epidemiology
  • Masked Hypertension* / metabolism
  • Middle Aged
  • Risk Factors
  • United States / epidemiology


  • Calcium