[Lichenoid drug reactions]

Hautarzt. 2018 Feb;69(2):116-120. doi: 10.1007/s00105-017-4117-y.
[Article in German]

Abstract

Lichenoid drug reactions are rare compared to typical morbilliform drug exanthema or urticaria. They are associated with specific drugs or drug families like gold, antimalarial drugs, β‑blockers and angiotensin-converting-enzyme inhibitors. Recent observations included associations with novel drugs such as biologics (e. g. tumour necrosis factor antagonists) and immune checkpoint inhibitors (anti-programme cell death protein 1 antibodies). Lichenoid drug reactions most often resemble lichen planus mainly in areas of ultraviolet-light exposed skin, but also mucosal lichen planus and even bullous lesions may occur.

Keywords: Anti-PD-1 antibodies; Biosimilars; Gold; Interferons; TNF-α antagonists.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects
  • Adrenergic beta-Antagonists / therapeutic use
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Antibodies / adverse effects
  • Antibodies / therapeutic use
  • Antimalarials / adverse effects
  • Antimalarials / therapeutic use
  • Biological Products / adverse effects
  • Biological Products / therapeutic use
  • Biosimilar Pharmaceuticals / adverse effects
  • Biosimilar Pharmaceuticals / therapeutic use
  • Drug Eruptions / diagnosis*
  • Gold Compounds / adverse effects
  • Gold Compounds / therapeutic use
  • Humans
  • Interferons / adverse effects
  • Interferons / therapeutic use
  • Lichenoid Eruptions / chemically induced*
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Antibodies
  • Antimalarials
  • Biological Products
  • Biosimilar Pharmaceuticals
  • Gold Compounds
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • Interferons